Open access
Sep 2026
A human iPSC-based perfusable and membrane-free neurovascular unit-on-chip connecting brain organoids to the blood–brain barrier
The blood–brain barrier (BBB) protects the central nervous system by restricting entry of harmful blood-borne factors, but this selectivity actively limits delivery of therapeutics to the brain. Because BBB function is shaped by dynamic interactions within the neurovascular unit (NVU), particularly between brain endoth...
Henrique Nogueira Pinto, Lois Kistemaker, Mikhail Ponomarenko et al.
· Lab on a Chip · 0 citations