Author

Arvind H. Patel

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Open access Jul 2026

SARS-CoV-2 Spike H655Y drives protease preference but does not dictate cellular tropism

This work reframes the understanding of coronavirus spike evolution, revealing that tissue tropism operates through mechanisms fundamentally distinct from those dictating protease preference, and that protease preference and tissue tropism are mechanistically uncoupled.

Diego Cantoni, Wilhelm Furnon, S. Little et al. · bioRxiv · 0 citations