Author

As Nguyen

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Open access Sep 2026

Molecular basis of nick ligation in the nucleosome by DNA Ligase IIIα

Genomic DNA is packaged into chromatin through a fundamental repeating unit known as the nucleosome core particle. Chromatinized genomic DNA is constantly exposed to endogenous and exogenous stresses that result in DNA damage, which must be repaired to maintain genome stability. Single-strand breaks (SSBs) are a preval...

Daniel J. Boesch, Nadia I. Martin, Chantal A. Kontor et al. · Nature Communications · 0 citations