Soil bacteria colonize plants without causing visible disease, yet many suppress host growth. The prevalence and evolutionary reach of this cryptic inhibition are unknown, because phenotyping hundreds of isolates in plants is prohibitively slow. Here we use the unicellular algae Chlamydomonas reinhardtii as a scalable...
Tzila Vikinyanski, Elad Meilin, Andrei Makhon et al.· bioRxiv· 0 citations
The type VI secretion system (T6SS) is a molecular harpoon used by 19% of sequenced bacteria to inject toxic proteins into microbial competitors or host cells. Despite its widespread distribution, many T6SS effectors (T6Es) remain unidentified in bacterial genomes. Here, we developed an XGBoost classifier integrating 4...
Avital Akerman-Arad, A. Danov, Yuval Chausho et al.· bioRxiv· 0 citations
Metabolic networks are highly interconnected. Still, it remains unclear whether organism-and environment-specific factors shape their capacity to evolve in response to metabolic stress or whether it follows general principles. Here, we studied metabolic evolvability in Bacillus subtilis using auxotrophic mutants lackin...
A scalable and adaptable microbial biotechnology platform for the scalable recombinant production of highly toxic bacterial proteins based on transient intramolecular toxin neutralization and the integration of transient intramolecular neutralization with computational engineering is presented.
R. Fraenkel, Inbar Cahana, Tomer Sivan et al.· bioRxiv· 0 citations
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