Asher Preska Steinberg

Recurrent non-canonical proteoforms in acute myeloid leukemia identified by integrative proteogenomics

Reference proteomes incompletely represent proteins translated in cancer, leaving tumor-specific proteoforms outside the search space of conventional mass spectrometry (MS). Such “dark proteome” products may arise from genomic variation, aberrant transcription or splicing, and non-canonical translation, including micro...