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Author

Ashish Verma

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Open access Oct 2026

PARP1 directly disassembles nucleosomes to regulate DNA repair.

Upon DNA damage, chromatin remodeling is rapidly initiated to promote chromatin accessibility. Although this enhanced accessibility has been linked to poly(ADP-ribose) polymerase (PARP) activity, how cells overcome the nucleosome barrier remains unclear. We discovered that PARP1 directly and asymmetrically evicts histo...

Ashish Verma, Chang-Lei Zhu, Bernadette Truong et al. · 0 citations

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