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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Ashley B. Niesman

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Open access Jul 2026

Preclinical characterization of a reversible XPO1 inhibitor for cancer therapy

The authors design and characterise FR-027, a reversible covalent inhibitor of XPO1 that does not induce XPO1 degradation, demonstrating strong antitumour activity, including in brain tumours, with an improved safety profile in mice.

Janne Van Hauwenhuyse, F. Reniers, L. Persoons et al. · 0 citations

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