Ashley Maliakal

Chronic manganese exposure disrupts dopamine biosynthesis and amphetamine response in a mouse model of altered dopamine transport.

The capacity for excess manganese to alter dopaminergic systems resulting in neurobehavioral deficits is clear, yet far less is known the impact of chronic, lower, sub-toxic manganese exposures. Manganese exposure may affect dopamine synthesis and metabolism, and as such impact drug efficacy. These may also occur to a...