Therapeutic cancer vaccines are increasingly tested in clinical settings alongside standard-of-care treatments that often include chemotherapy, yet whether chemotherapy synergizes with cancer vaccines remains unclear. Here, we tested heterologous prime-boost viral vector vaccines in combination with various chemotherap...
Laurine Noblecourt, Amanda Wicki, Ashwin K. Jainarayanan et al.· Cancer Cell· 0 citations
Microglia are the primary immune cells of the brain, but their role in Parkinson's disease is not fully understood. Chronic microglial activation is toxic to neurons, but in the early stages of pathology, microglia also exert beneficial functions. We used induced pluripotent stem cell (iPSC)-derived coculture models to...
Hung-Ju Chueh, Antigoni Katsikoudi, Ana Aragón-González et al.· Science Translational Medici...· 0 citations
Glioblastoma (GBM), a high-grade glioma, is the most common primary brain tumor in adults, with a dismal prognosis and a very high recurrence rate. Major challenges to effective treatment arise from the tumor’s locally aggressive, diffusely infiltrative nature and extensive intratumoral heterogeneity. Recent advances i...
Ashwin K. Jainarayanan, Aishwarya Vedula, Neeraj Soni· Frontiers in Neural Circuits· 0 citations
The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic and transcriptomic changes in human iPSC-derived dopaminergic neurons with increasing burden of pathological α-synuclein. We found that misfolded...
Chor Lai Lam, N. Gatford, Ana Aragón-González et al.· Nature Communications· 0 citations
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