Author

Assa Sherman

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Open access Jul 2026

Analysis of haploinsufficiency in human neural progenitor cells: insights into early molecular effects of autism-related genes.

This work differentiated a genome-wide heterozygous loss-of-function CRISPR library into neural progenitor cells (NPCs) and defined about 250 genes essential for neural differentiation in a haploinsufficient manner, and offers new insights into the embryonic molecular basis of ASD and other NDDs driven by gene dosage imbalance.

Roni Sarel-Gallily, Assa Sherman, Daniel Pollak et al. · Cell Death and Disease · 1 citation