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Author

Astha Neupane

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Open access Sep 2026

High-resolution CRISPR/Cas9 screens identify PAK2 as a suppressor of macrophage proliferation

Macrophage abundance is regulated by pathways controlling survival and proliferation, yet the genetic determinants of macrophage fitness remain poorly understood. Here, we performed replicate genome-wide CRISPR/Cas9 screens in primary murine bone marrow-derived macrophages (BMDMs) to identify positive and negative regu...

Kevin N. Wanniarachchi, Astha Neupane, Bidhi Kasu et al. · 0 citations

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