Author

Athira Perunelly Gopalakrishnan

3 papers indexed here

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Aug 2026

Phosphosite-Centric Association of MBD3 and NuRD Complex Based on Meta-Analysis of Global Human Phosphoproteome.

Methyl-CpG-binding domain protein 3 (MBD3) is a member of the methyl-CpG-binding domain (MBD) family, which functions as a scaffold within the nucleosome remodeling and histone deacetylase complex (NuRD). MBD3 has been studied extensively in pluripotency and gene regulation, particularly through chromatin remodeling. E...

Rachael Dsouza, Vaishnavi Gopalakrishnan, Leona Dcunha et al. · Omics · 0 citations

Aug 2026

Large-Scale Cellular Phosphoproteomic Analysis Reveals a Putative Role for LPIN1 S162 in Metabolic Signaling.

Lipin-1 (LPIN1) is a nucleocytoplasmic phosphatidate phosphatase and transcriptional coregulator that plays essential roles in lipid metabolism, insulin signaling, and energy homeostasis. Although LPIN1 function is extensively regulated by phosphorylation, the biological significance of individual phosphosites remains...

Bristow Ben Joseph, Pathiyil Sajini Sekhar, Athira Perunelly Gopalakrishnan et al. · Omics · 0 citations

Open access Aug 2026

Functional phosphoproteomic analysis of SMG1 in nonsense-mediated mRNA decay and DNA damage repair in cancer

Findings identify SMG1 as a central phosphorylation hub integrating nonsense-mediated mRNA decay with genome maintenance pathways and provide the first systematic phosphosite-centric framework for understanding its regulation.

Apoorva Pai, Leona Dcunha, Athira Perunelly Gopalakrishnan et al. · Frontiers in Systems Biology · 0 citations