Open access
Aug 2026
Efficient brain delivery and sustained retention of antibodies via dual targeting of blood–brain barrier and intra-brain proteins
The concept of achieving sustained high brain exposure by combining BBB transport with enhanced brain retention with binding to blood–brain barrier (BBB) proteins for enhanced BBB permeability was shown to be broadly applicable.
Yukihiro Noguchi, Naoka Hironiwa, Kazuki Sato et al.
· mAbs · 0 citations