Author

Atsuo Tamura

2 papers indexed here

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Open access Aug 2026

Small-molecule RAS/RAF inhibitors target RAS-driven cancers via allosteric RAF disruption

RAS, a frequently mutated cancer-driver gene, has been the focus of intensive research, with numerous inhibitors developed to target RAS and its signalling molecules. With the advent of approved subtype-specific RAS inhibitors targeting KRASG12C mutation, the development of RAS inhibitors that are effective regardless...

Y. Yoshikawa, Hirokazu Kubota, S. Matsumoto et al. · Nature Communications · 0 citations

Open access Sep 2026

Thermodynamic and Structural Determinants of Ni(II), Co(II), and Zn(II) Binding to an XHXXHXH Peptide Motif

Metal‐binding peptides serve as compact platforms for molecular recognition, catalysis, and responsive biomaterials, yet the sequence rules that govern their metal‐bound structures remain to be fully elucidated. Clarifying whether short histidine (H)‐rich motifs converge to preferred conformations upon metal binding is...

Kou Honda, Hitoshi Haneoka, Takeyuki Suzuki et al. · Journal of Peptide Science · 0 citations