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Author

Atsushi Shibata

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Open access Sep 2026

Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewed intestinal inflammation.

DNA ligase IV (LIG4) is essential for DNA double-strand break (DSB) repair. Hypomorphic LIG4 variants cause LIG4 syndrome, characterized by growth disturbance, increased radiosensitivity, predisposition to malignancies, adaptive immunodeficiency and inflammatory conditions. Most of these manifestations are recapitulate...

Yusuke Yamashita, Hideki Kosako, Takashi Kato et al. · 0 citations
Open access Sep 2026

IDH3-dependent mitochondrial function in stromal fibroblasts suppresses malignant tumor growth

Findings identify IDH3α-dependent mitochondrial function in fibroblasts as a critical determinant of tumor progression and suggest that stromal mitochondrial metabolism represents an important axis for modulating tumor behavior.

L. R. Koseki, Minoru Kobayashi, Mai Ito et al. · 0 citations

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