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Atsushi Takahashi-Kanemitsu

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Review Open access Sep 2026

Differential tyrosine phosphorylation status of the nuclear scaffold Parafibromin/CDC73 determines its role in cancer development.

Parafibromin/CDC73 is a multifunctional nuclear scaffold protein with context-dependent roles in tumorigenesis, functioning as both a tumor suppressor and an oncogenic driver. Originally identified as the product of the HRPT2 tumor suppressor gene, which is mutated in hyperparathyroidism-jaw tumor syndrome, Parafibromi...

Atsushi Takahashi-Kanemitsu, Ippei Kikuchi, N. Murata-Kamiya et al. · 0 citations
Open access Jul 2026

Colorectal cancer co-opts an epidermal wound healing program during metastasis to generate disseminated tumor cells

It is shown that CRC cells transiently adopt a wound-healing program normally used by epidermal keratinocytes during tissue repair to enable metastatic dissemination, and this state is reversible, as cells reacquire primary tumor–like characteristics upon colonization of distant organs.

M. Sakahara, Takuya Okamoto, Kohei Kumegawa et al. · 0 citations

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