Author

Atul Deshpande

2 papers indexed here

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Open access Sep 2026

36 Clear Cell Renal Cell Carcinoma Consensus Transcriptomic Programs Reveal Converging Trajectories Towards Aggressive Disease

Abstract Background Clear cell renal cell carcinoma (ccRCC) is characterized by a branching genomic architecture in which biallelic VHL inactivation is followed by divergence into PBRM1- or BAP1-mutant lineages, with subsequent acquisition of additional alterations contributing to progression and aggressive behavior. H...

Roy Elias, Vivek Nimgaonkar, B. Xie et al. · The Oncologist · 0 citations

Open access Sep 2026

Interpretable spherical geometry of single-cell state transitions from dominant principal components

Single-cell RNA-seq atlases are commonly explored with nonlinear embeddings that preserve neighborhoods but provide limited coordinate-level interpretation. We asked whether projecting the dominant principal components (PCs) of single-cell gene expression onto a unit sphere would yield an interpretable coordinate syste...

Long Yuan, Xu-Yang Li, My Le et al. · bioRxiv · 0 citations