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Author

Augustus J. Lowry

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Review Sep 2026

Lipid flip-flop in biological membranes: through the lens of TMEM16F

The biology of regulated transmembrane phospholipid flip-flop mediated by lipid scramblases is examined, using TMEM16F as a prototypical model to illustrate core molecular mechanisms, physiological functions, pathological implications, and emerging pharmacological opportunities.

Shan Z. Ke, Augustus J. Lowry, Maria A. Gonzalez Torres et al. · 0 citations
Open access Aug 2026

A TMEM63B variant with enhanced mechanosensitive channel activity and acquired lipid scramblase function

A stratified molecular model of TMEM63B channelopathies in which the pathogenic variants progressively destabilize the hydrophobic gate, permitting lipid permeation at the resting state followed by force-induced ion and lipid co-transport through I475del is supported.

Augustus J. Lowry, P. Liang, Maria A. Gonzalez Torres et al. · 0 citations

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