The control of crystallization processes in polymorphic systems remains a long-term goal at both laboratory and industrial scales. The rational design of processes that yield specific, desired crystal structures with suitable physical properties requires not only phase equilibrium data but also insights into the rela...
P. Cardew, Aurora J. Cruz-Cabeza, R. J. Davey et al.· Crystal Growth & Design· 0 citations
HEPES (2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-1-sulfonic acid) is a widely used buffering agent in biological and biomedical research. Here, we reveal an exceptional solid-form landscape for HEPES. In addition to the two previously known polymorphs, we discover and characterize three new polymorphs and three new...
Amy Woods-Ryan, Amrita Chattopadhyay, G. Novelli et al.· Crystal Growth & Design· 0 citations
Hydrates are common solid forms that can significantly affect a compound’s stability, physicochemical properties, and commercial viability. Despite their importance in pharmaceutical development, hydrate structures, their relationship to material properties, and their propensity for formation remain poorly understood...
Henry A. Holleb, Fragkoulis Theodosiou, Pablo Martinez-Bulit et al.· Crystal Growth & Design· 0 citations
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