Author

Austin Hartman

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Open access Aug 2026

Genome-scale perturb-seq in primary human CD4+ T cells maps context-specific regulators of T cell programs and human immune traits

This study perturbed all expressed genes across 22 million primary human CD4+ T cells from four donors and developed a probe-based perturb-seq platform to measure the transcriptome effects in cells at rest and after stimulation, allowing it to map genes regulating immune pathways, including previously uncharacterized r...

Ronghui Zhu, E. Dann, Jun Yan et al. · Cell · 1 citation

Open access Aug 2026

Synthetic transcription factors designed by domain recombination enhance CAR T cell antitumor function.

It is demonstrated that reconfiguring existing protein domains may uncover non-evolved genes that program therapeutically relevant cell states that program therapeutically relevant cell states.

Oliver Takacsi-Nagy, Sivakanthan Kasinathan, Austin Hartman et al. · Cell · 0 citations