Review
Open access
Sep 2026
PIM1 in myeloproliferative neoplasms: potential pathogenic and therapeutic implications.
Myeloproliferative neoplasms (MPNs) are clonal hematologic malignancies characterized by the overproduction of mature myeloid lineage cells. Although JAK2 inhibitors, such as ruxolitinib, can alleviate constitutional symptoms, they typically fail to eradicate malignant clones or reverse bone marrow fibrosis. Moreover,...
Avik Dutta, L. Varricchio, Ronald Hoffman et al.
· Leukemia · 0 citations