Aya M. Abd El-latif

Involvement of JAK2/STAT3, PI3K/AKT/mTOR, and M1/M2 microglial polarization in the possible effects of baricitinib for mitigating reserpine-induced fibromyalgia in rats.

Fibromyalgia (FM) is a chronic pain disorder characterized by widespread musculoskeletal pain accompanied by fatigue, mood disturbances, and sleep abnormalities. Baricitinib, a selective Janus kinase (JAK) 1/2 inhibitor, has potent anti-inflammatory and immunomodulatory effects and is approved for various resistant inf...