Engineering the acid-tolerant yeast Issatchenkia orientalis for efficient lactic acid production via optimized glucose and xylose utilization
The acid-tolerant yeast Issatchenkia orientalis is a promising platform for the sustainable production of organic acids. However, the inefficient conversion of lignocellulosic biomass-derived sugars, primarily due to carbon catabolite repression (CCR), reduces overall production efficiency and limits its industrial app...