Abstract B079: Comprehensive expression atlas of chemokine ligands and receptors reveals endothelial ACKRs as regulators of immune exclusion in human PDAC
Pancreas cancer remains a devastating disease with an immunologically cold microenvironment that resists immunotherapies. Because immune cell recruitment is dependent on chemokine signaling, clinical trials targeting chemokine receptors have shown limited benefit due to signaling redundancy. We hypothesized that the...