Epigenetic Rewiring and Context‐Dependent Therapeutic Vulnerabilities in Myeloproliferative Neoplasms
Myeloproliferative neoplasms (MPN) are shaped by epigenetic rewiring that extends beyond canonical JAK2V617F‐driven signaling. This review argues that context‐dependent chromatin states, not merely genetic lesions, determine disease trajectory, fibrotic transformation, and leukemic progression. We synthesize recent evi...