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A COMPARATIVE STUDY OF ROPIVACAINE AND ROPIVACAINE WITH DEXMEDETOMIDINE IN TRANSVERSUS ABDOMINIS PLANE BLOCK FOR POST-OPERATIVE ANALGESIA AND EARLY MOBILIZATION IN PATIENTS UNDERGOING ELECTIVE INGUINAL HERNIORRHAPHY
Objectives: This study aimed to compare the efficacy of ropivacaine alone and ropivacaine with dexmedetomidine, which is used for transversus abdominis plane block (TAP) in patients undergoing inguinal hernia repair. The primary outcome was the time to first request for rescue analgesia (defined as Visual Analog Scale...
Dasatinib as a Network-modulating Tyrosine Kinase Inhibitor in Philadelphia Chromosome-positive Leukemias: Integration of BCR-ABL1, SRC, and MAPK Signaling
This review combines many forms of evidence, including mechanistic, phosphoproteomic, immunologic and clinical evidence, to show that dasatinib acts as a network-modulating tyrosine kinase inhibitor rather than only as an ABL1-directed agent.