Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be con...
Sarah J. Shemtov, Eric Hwang, Claire S. Chung et al.· bioRxiv· 0 citations
A large portion of eukaryotic genomes is composed of transposable elements, which are usually kept repressed in young, healthy cells but can be derepressed in response to cell senescence and organismal aging. LINE-1 (L1) is the most abundant TE in the human genome by percent coverage, and its derepression has been impl...
Juan I. Bravo, Eyael Tewelde, C. D. King et al.· bioRxiv· 0 citations
It is demonstrated that MOTS-c (mitochondrial open reading frame from the 12 S rRNA type-c) is a mitochondrial-encoded amphipathic and cationic peptide with direct antibacterial and immunomodulatory functions, consistent with the peptide chemistry and functions of known HDPs.
Michelle C. Rice, M. Imun, Sang-Wun Jung et al.· eLife· 0 citations
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