Author

B. Bhinder

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Open access Aug 2026

A compendium of next-generation patient-derived models for diverse cancers

A large-scale international programme—the Human Cancer Models Initiative—is presented, which involved the generation of a resource of 665 next-generation models from 2,780 donors with 25 cancer types and integrated tumour–model whole genome, exome, methylome and transcriptome analyses.

Dina Elharouni, Mushriq Al-Jazrawe, Seongmin Choi et al. · Nature · 7 citations

Open access Aug 2026

Role of orphan G protein-coupled receptor GPR52 in breast cancer cell multicellular organization and collective invasion.

Loss of the orphan GPCR GPR52 in human breast cell lines leads to increased cell clustering, hybrid/partial EMT, and increased tumour burden in zebrafish, further expanding the understanding of mechanisms driving cancer progression and opening the door to novel therapeutic approaches.

Sarah Z. Hanif, Caleb Kutz, C. C. Au et al. · British Journal of Cancer · 0 citations