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Preoperative Glymphatic Asymmetry Is Associated with Motor Outcomes Following STN-DBS in Parkinson's Disease.
BACKGROUND Interindividual variability in motor outcomes after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) remains incompletely understood. Glymphatic-related imaging abnormalities have been reported in PD, but their relevance to neuromodulation response is unclear. OBJECTIVES To...
Prognostic significance of cerebrospinal fluid tau biomarkers in amyloid-negative A−T + N + neurodegeneration: A retrospective cohort study
Background Amyloid-negative tau-related neurodegeneration represents a non-Alzheimer biomarker-defined profile; however, its clinical heterogeneity and prognostic relevance remain unclear within Alzheimer's disease-related frameworks. Objective To characterize the clinical spectrum and identify predictors of mortality...