The Thymic Microenvironment Shapes Age‐Related Qualitative Changes in the TCR Repertoire
Ageing impairs immune function, increasing susceptibility to infection, autoimmunity and inflammation. The thymus undergoes involution during childhood, and thymocyte and thymic epithelial cell (TEC) numbers decline. Given that adaptive immunity depends on T‐cells recognising diverse antigens via their unique T‐cell re...