Author

B. Cicali

2 papers indexed here

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Open access Oct 2026

Integrating Static and Dynamic Models to Predict Cannabidiol-Mediated Metabolic Drug-Drug Interactions.

Cannabidiol (CBD) inhibits multiple cytochrome P450 (CYP450) enzymes in vitro via reversible and time-dependent mechanisms, raising concerns for metabolic drug-drug interactions (DDIs). Clinical DDI data for CBD are limited, and the translation of in vitro derived inhibition parameters into in vivo DDI predictions rema...

Sulafa Abdulla Alsahlawi, Bassma Eltanameli, B. Cicali et al. · Clinical pharmacology and th... · 0 citations

Review Open access Sep 2026

Integrating Patient-Centric Clinical Pharmacology and MID3 to Advance Biologic Development in Immune-Mediated Inflammatory Diseases.

Advances in biologics and model-informed drug discovery and development (MID3) are transforming the treatment of immune-mediated inflammatory diseases (IMIDs). By integrating pharmacokinetics and pharmacodynamics, MID3 enables mechanism-based, patient-centered strategies to optimize therapies, strengthen benefit-risk a...

Sihem Ait-Oudhia, Li Zhang, D. Pisal et al. · Clinical pharmacology and th... · 0 citations