Author

B. D. Boon

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Oct 2026

Generalizing Amyloid Î² Pathology from Postmortem Human Brains with Vision Foundation Models for Lesion Quantification

By replacing empirical, from-scratch architectures with a generalizable foundation model adapter framework, ViTamyloid provides a highly sensitive scalable digital pathomics toolkit, offering objective, quantitative endpoints for Alzheimer's disease clinical trials and disease subtyping.

Y. Chen, B. D. Boon, E. Engelberg-Cook et al. · medRxiv · 0 citations

Open access Sep 2026

Presynaptic accumulation of APP-CTFβ may contribute to synaptic dysfunction in Alzheimer’s disease

It is shown that endogenous APP and its proteolytic C-terminal fragments (APP-CTFs), the precursors of amyloid-β (Aβ), are enriched at excitatory synapses, and that APP processing generates functionally distinct intermediates at the synapse, i.e. presynaptic APP-CTFβ, which can accumulate in the active zone of excitato...

Akshay Kapadia, Fabian Schuhmann, Ezgi Daskin et al. · EMBO Journal · 0 citations