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Author

B. D. de Groot

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Open access Oct 2026

Lipid gating of BK channels and activation mechanism by negatively charged lipids

BK channels are a class of K+ channels that possess an unusually high conductance and are synergistically gated by intracellular Ca2+ and voltage. Despite the significant array of experimental and computational data, many aspects of their function and dynamics remain unclear - such as how ion permeation is halted in th...

A. Mironenko, B. D. de Groot, Wojciech Kopec · 0 citations
Open access Sep 2026

Gating crosstalk in potassium channels

This work identifies a conserved gating crosstalk mechanism linking the activation gate to the width of the selectivity filter entrance, which regulates ion permeation rate by tuning ion occupancy at the selectivity filter.

Lyubin Hu, B. D. de Groot, Ruo-Xu Gu · 0 citations

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