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B. Deneen

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Open access Sep 2026

Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea

Pediatric obstructive sleep apnea (POSA) is a common childhood disease that often causes aberrant brain development and cognitive deficits. The pathophysiological underpinnings of cognitive impairments in POSA remain unclear. Here, we examined cellular and molecular aspects of pathology in a mouse model of POSA that fe...

Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour et al. · 0 citations
Aug 2026

Astrocytic NFIX regulates thalamocortical circuits through GABA and purinergic signaling.

These studies identify region-specific roles for astrocytic NFIX and its gene regulatory network in TRN astrocytes, while further revealing that astrocytes in the TRN couple regulation of thalamocortical circuit dynamics and memory formation through parallel GABA and purinergic signaling pathways.

Sanjana Murali, Manuel Silva-Pérez, Jun-Sung Woo et al. · 0 citations

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