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Open access Oct 2026

β3‑adrenergic receptor agonist improves recovery after volumetric muscle loss and is associated with increased intramuscular brown/beige adipogenic activity in mice

Volumetric muscle loss (VML) often results in chronic muscle weakness, limb dysfunction, and even permanent disability. Current research primarily focuses on cell and extracellular matrix transplantation, but there is a lack of studies on the physiologically supportive intervention to enhance endogenous muscle re...

Zi-Li Wang, Da-Chong You, Zi-Peng Xie et al. · 0 citations
Aug 2026

Heterogeneous human muscle fibroadipogenic progenitors include a DLK1+ subpopulation that prevents fatty infiltration after injury.

This work defined molecularly distinct, clinically relevant human FAP subpopulations, established DLK1 as a regulator of adipogenic potential in vivo, and provided a framework to identify pathogenic FAP states that may be used in the pursuit to prevent maladaptive muscle remodeling.

Steven M Garcia, J. Lau, A. Diaz et al. · 0 citations

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