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Author

B. Freudenthal

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Aug 2026

Human nuclear ribomes reveal DNA-embedded ribonucleotides as epigenetic modulators of transcription-associated DNA supercoiling.

A non-random nuclear "ribome," the genome-wide landscape of embedded rNMPs, enriched in GC-rich regions, regulatory elements, and telomeres, is revealed, revealing a connection between ribonucleotide processing and transcription-associated DNA topology in human cells.

Deepali L. Kundnani, Yeunsook Lee, Taehwan Yang et al. · 0 citations
Open access Aug 2026

XRCC1 Enables the Efficient Local Search for DNA Damage by DNA Polymerase Beta

It is demonstrated that XRCC1 reshapes pol β search behavior to promote efficient local damage recognition, providing a mechanistic basis for how BER factors coordinate lesion detection and processing to maintain genomic stability.

Spencer H. Thompson, Kaitlin M. DeHart, M. Schaich et al. · 0 citations

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