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B. Giuliani

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Open access Aug 2026

Canonical and non-canonical miRNA degradation shapes state transitions and stemness in breast cancer

Target-directed microRNA degradation (TDMD) is an emerging post-transcriptional mechanism that controls miRNA turnover, yet its role in human cancers remains largely unexplored. Here, we combine CRISPRi-mediated ZSWIM8 depletion, miRNA-seq, and AGO2-eCLIP to define the TDMD landscape across breast cancer subtypes. We i...

C. Rubolino, Manfredi D'Onghia, Chiara Tordonato et al. · 0 citations

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