Author

B. Glimelius

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Open access Sep 2026

Heterozygous germline mutations in MSH3, and probably MLH3, act as classical tumour suppressors, leading to excess somatic deletion mutations, signature ID4 and increased colorectal cancer risk.

BACKGROUND MSH3 and MLH3 are non-canonical DNA mismatch repair genes, involved in repairing insertion-deletion mutations. Colorectal cancer (CRC) and adenomas have been reported in patients with bi-allelic germline MSH3 mutations, and in a very few bi-allelic MLH3 mutation carriers. OBJECTIVES We hypothesised that ge...

I. Soriano, K. Sherwood, Joseph C. Ward et al. · Gut · 0 citations

Review Open access Aug 2026

Treatment strategies and oncological outcomes across national guideline periods in rectal cancer: a population-based cohort study

The findings support a more selective radiotherapy use while maintaining oncological safety and reducing treatment-related morbidity in patients with clinical stage I–III rectal cancer treated with curative intent.

S. Doroudian, E. Osterman, B. Glimelius · British Journal of Surgery · 0 citations