Author

B. Gomperts

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Open access Oct 2026

p53 activation via pharmacologic MDM2 inhibition constrains exhaustion and enhances antitumor function of human CD8+ T cells

Adoptive T-cell therapies using chimeric antigen receptors (CARs) or engineered T-cell receptors (TCRs) have transformed cancer treatment but remain limited by poor persistence and progressive T-cell exhaustion. Manufacturing strategies that promote memory T-cell formation may improve therapeutic durability. Here we...

Alexandra Boix de Jesus, Hy B. Dao, Anthony Imani et al. · Frontiers in Immunology · 0 citations

Open access Aug 2026

Double-stranded DNA donors and CRISPR-Cas9 for universal correction of mutations causing cystic fibrosis in human airway cells

These results demonstrate that low levels of CFTR integration can be made therapeutically relevant by optimizing the designs of gene editing reagents, an essential step toward in vivo gene therapy for CF.

Vrishti Sinha, P. Ayoub, C. Juett et al. · Molecular Therapy: Nucleic A... · 0 citations