Leucine-rich repeat-containing G protein-coupled receptor 5 (LGR5) marks a stem-like colorectal cancer population but is difficult to target directly because of its expression in normal intestinal stem cells. Here, we integrated transcriptomic, somatic mutation, and copy-number data from 396 colorectal tumors to define...
Lucía Paniagua-Herranz, A. Feito, Cristian Privat et al.· bioRxiv· 0 citations
The Mediterranean diet (MedDiet) is well established for its cardiometabolic benefits and has increasingly been linked to reduced cancer risk. While protective associations with colorectal cancer are consistently reported, evidence for other gastrointestinal and upper aerodigestive malignancies remains less comprehensi...
Z. Ungvari, M. Fekete, P. Varga et al.· GeroScience· 0 citations
Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimization of multiple interdependent parameters,...
Alberto Ocaña, J. R. Espinosa, C. Alonso-Moreno et al.· Signal Transduction and Targ...· 0 citations
LGR5 expression defines a colorectal cancer subset that is pharmacologically tractable despite the absence of genetic dependency, including condensate-directed modulation of NKD1 as a route to targets inaccessible by antibody- or pocket-based approaches.
Lucía Paniagua-Herranz, A. Feito, Cristian Privat et al.· bioRxiv· 0 citations
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