B. K. Dukka

TaHL-PTM: Post-Translational Modification Prediction in Proteins via Target-Hooked Discriminative Fine-Tuning of Decoder-only Protein Language Models

TaHL-PTM (Target-Hooked Low-rank adaptation for PTM prediction), a novel framework that integrates target-hooked tokenization with site-directed discriminative LoRA fine-tuning that generalizes across models with different pretraining tokenization schemes is proposed.