Author

B. Keele

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Open access Sep 2026

BCL-2 inhibition at antiretroviral therapy initiation reduces the intact SIV reservoir in macaques.

The anti-apoptotic molecule BCL-2 favours the maintenance of the CD4+ T-cell reservoir during HIV infection. Whether inhibition of BCL-2 can lead to long-term reduction of the HIV reservoir is unclear. Here we initiated antiretroviral therapy (ART) in 24 simian immunodeficiency virus (SIV)-infected rhesus macaques at 1...

T. R. Wiche Salinas, J. Harper, C. Deleage et al. · Nature Microbiology · 0 citations

Open access Sep 2026

Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection.

People living with HIV (PLWH) on suppressive antiretroviral therapy (ART) can face non-AIDS complications, partially driven by chronic immune activation. To define immune perturbations during ART-suppressed viral infection, we performed longitudinal single-cell transcriptomic and plasma proteomic analyses of rhesus mac...

Maanasa Kaza, B. Varco-Merth, G. McElfresh et al. · Cell Reports · 0 citations

Open access Sep 2026

Tissue Origins and Immune Correlates of Viral Rebound in SIV-Infected Rhesus Macaques Following ART Discontinuation

The majority of persons living with HIV-1 who discontinue antiretroviral therapy (ART) demonstrate viral rebound, but the tissue-level events that lead to rebound viremia remain poorly understood. Here we report the origin, dynamics, and correlates of viral rebound in 16 rhesus macaques (RMs) infected with molecularly...

Irena V. King, Malika Aid, Emek Kose et al. · Science Translational Medici... · 0 citations