Author

B. Klaholz

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Open access Oct 2026

A ribosomal pseudouridine drives an oncogenic translation program

Ribosome heterogeneity can regulate translation, but how changes in ribosome chemistry reshape cellular programs and contribute to diseases such as cancer remains incompletely understood. Here we show that SNORA81-guided pseudouridylation at a single 28S ribosomal RNA site, U4636, links ribosome heterogeneity to select...

Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al. · bioRxiv · 0 citations

Open access Oct 2026

A ribosomal pseudouridine drives an oncogenic translation program

Dynamic ribosome heterogeneity has emerged as a potential layer of translational regulation, but whether variation in ribosomal RNA (rRNA) modification stoichiometry can selectively control the translation of mRNAs with shared encoded features remains unclear. Here we show that SNORA81-guided pseudouridylation at U4636...

Laurence Faucher-Giguère, Andrea Rivera-Pizana, Baudouin Seguineau de Préval et al. · bioRxiv · 0 citations

Open access Jul 2025

Translation initiation by the Kozak mRNA sequence is based on a conformational readout on the ribosome

The cryo-EM structures of human 48S preinitiation complexes with mRNA point mutations reveal a fan-like intercalation of the pre-codon triplet into the 18S ribosomal RNA (rRNA), while the -3 purine as opposed to the pyrimidine in the non-Kozak context favours stabilization of the ternary complex between initiation fact...

O. von Loeffelholz, Charles Barchet, Samuel Holvec et al. · bioRxiv · 2 citations