Open access
Aug 2026
Generation of human induced pluripotent stem cell lines from relatives of an unexplained sudden cardiac death victim carrying a Brugada Syndrome-associated, SCN5A c.287 T > C, variant.
Patient-derived induced pluripotent stem cells (hiPSC) are a valuable approach to model cardiovascular diseases and nucleofected non-integrating episomal vectors in skin fibroblasts of four family members are a reliable source to study the effect of the identified mutation in a physiologically relevant environment.
E. Selga, R. Martínez-Moreno, Albert Rigat Pujolàs et al.
· Stem Cell Research · 0 citations