Author

B. Kuster

3 papers indexed here

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Open access Sep 2026

MACC1 Hyperactivates Receptor Tyrosine Kinase Signaling Through Phosphorylation-Dependent Adaptor Activity in Colorectal Cancer Cells

Understanding the mechanisms of metastasis is one of the most pressing issues in cancer therapy. Metastasis-associated in colon cancer 1 (MACC1) is an important biomarker and functional driver of tumor progression and metastasis. However, the molecular mechanisms underlying its activity remain incompletely understood....

Fabian Zincke, D. Kobelt, Susan Kläger et al. · Biomolecules · 0 citations

Open access Aug 2026

Chemoproteomics identifies a pyrimido[4,5-d]pyrimidine analogue as a tubulin-tyrosine ligase binder

This work serendipitously identified CEM198 as the first high-affinity ligand of tubulin-tyrosine ligase (TTL), introducing CEM198 as a chemical probe for investigating the tubulin tyrosination–detyrosination and demonstrating the potential of chemoproteomics to uncover novel modulators of microtubule dynamics.

Rubaba R. Abanti, Eleftheria A. Georgiou, D. Makarov et al. · bioRxiv · 0 citations

Open access Aug 2026

A STRUBBELIG–NHL3 cell surface receptor complex mediates the response to cellulose deficiency in Arabidopsis

This study shows that signalling by the multifunctional receptor kinase SUB in cell wall integrity involves two functionally distinct cell surface complexes whose activities are attenuated by sequential endocytosis, revealing a stress–growth trade-off.

Rodion Boikine, Ajeet Chaudhary, J. Mergner et al. · Nature Plants · 1 citation