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Author

B. Marambe

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Sep 2026

Discovery and Structural Basis of Zoledronic Acid as a Potent SPS-Targeting Herbicide.

Solanesyl diphosphate synthase (SPS) is essential for plastoquinone-9 (PQ-9) biosynthesis and has emerged as a promising target for herbicide discovery. The commercial SPS herbicides bind to the dimer interface of the protein; however, substrate-competitive SPS inhibitors are still rare, particularly in agronomically r...

Min Li, Si-Mei Zhou, Jian-Guo Wei et al. · 0 citations
Oct 2026

Synthesis and biological characterization of formononetin derivatives against phytopathogenic oomycete and bacteria: preliminary mechanisms, theoretical predictions, and biosafety evaluation.

BACKGROUND The increasing prevalence of phytopathogenic oomycetes and bacteria, particularly Phytophthora capsici (Pc) and Xanthomonas oryzae pv. oryzae (Xoo), poses severe threats to global agricultural production. Developing novel antimicrobial agents with dual antimicrobial activities, multiple mechanisms of action,...

Fang Tian, Jun-Rong Song, Ming-Man Sun et al. · 0 citations
Open access Oct 2026

Design, synthesis, and evaluation of antifungal and antibacterial activities of novel quinazolinone-formononetin derivatives.

BACKGROUND Plant pathogenic fungi and bacteria cause substantial losses in agricultural production worldwide, and escalating resistance to conventional agrochemicals necessitates the development of novel, environmentally benign pesticides. Formononetin, a naturally occurring isoflavone, exhibits promising bioactivities...

Xiao-Yan Pan, Jun-Rong Song, Qing-Xue Hu et al. · 0 citations
Jul 2026

Design, Synthesis, and Antifungal Activity of Thiazolidinedione Derivatives Incorporating Thioamide and Piperidine Moieties.

A series of thiazolidinedione derivatives containing thioamide and piperidine moieties were designed, synthesized, and evaluated for antifungal activity against plant pathogenic fungi. Several compounds exhibited potent antifungal activity, among which Z17 was the most active against Rhizoctonia solani (EC50 = 1.8 μg/m...

Junrong Song, Shuang Feng, Miaohe Zhang et al. · 0 citations
Aug 2026

Novel Flavonol Derivatives Bearing a 1,2,3,4-Tetrahydroquinoline Moiety: Design, Synthesis, and Anti-Phytophthora capsici Activity.

Mechanistic studies revealed that Q8 disrupted cell membrane integrity and inhibited succinate dehydrogenase (SDH) activity, with computational simulations suggesting a higher binding affinity for SDH than fluopyram.

Qing-Xue Hu, Xiao-Ting Geng, Fang Tian et al. · 0 citations

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