B. Merkely

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial

Integrating volumes into myocardial work: the prognostic role of non-invasive pressure-strain-volume analysis in transcatheter aortic valve implantation.

The accurate echocardiographic assessment of the left ventricular (LV) contractile state remains challenging in aortic stenosis, as ejection fraction and even global longitudinal strain are markedly load-dependent. The novel pressure-strain loop-derived myocardial work were developed to overcome this limitation; howeve...

Predictors of echocardiographic response in the Budapest-CRT upgrade trial.

BACKGROUND AND AIMS Up to 30% of patients fail to respond after cardiac resynchronization therapy (CRT). While echocardiographic predictors of response are well described in de novo CRT, evidence in CRT upgrade populations remains limited. We investigated predictors of echocardiographic response in the BUDAPEST-CRT Upg...

Survodutide Once Weekly in Adults with Obesity and Type 2 Diabetes.

BACKGROUND For persons living with both type 2 diabetes and obesity, weight management may be the most effective therapy for type 2 diabetes. Glucagon-like peptide-1 (GLP-1) receptor agonists have potent weight-reducing effects, and other mechanisms may confer additional benefits. Survodutide is an investigational gluc...

Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.

Chronic occupational stress is increasingly recognized as a modifiable accelerator of biological aging, yet it remains underappreciated as a target of geroscience-informed public health intervention. This review reframes workplace stress as a life-course determinant of aging trajectories and introduces a translational...

Significance of Cardiac Troponin in Cancer Patients

The pathological conditions that cause elevated serum cardiac troponin levels in patients with malignancies are summarized and the underlying mechanisms at the molecular and cellular levels are explored and potential clinical applications are discussed.

Prophylactic implantation of implantable cardioverter-defibrillator for the primary prevention of sudden cardiac death after myocardial infarction: protocol for systematic review and meta-analysis of randomised controlled trials

A systematic review and meta-analysis will evaluate and provide primary evidence for the effectiveness of prophylactic implantation of TV-ICDs on all-cause mortality in patients who experienced MI, aiming for primary prevention of SCD after MI.