This study establishes large-scale adipocyte cell villages as a powerful and generalizable framework to map the context-dependent regulatory architecture of cardiometabolic disease and provides a resource linking human genetic variation to adipocyte cellular programs.
Yi Huang, Joaquin Perez-Schindler, Sanchari Datta et al.· bioRxiv· 0 citations
A significantly elevated genome-wide rare CNV burden in EAS cases compared with controls is observed, underscoring the importance of increasing population diversity to fully capture the genetic underpinnings of schizophrenia.
Yu Chen, Qi-Di Feng, Max Lam et al.· Nature Genetics· 0 citations
Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...
L. Hu, T. Tan, K. Yuan et al.· medRxiv· 0 citations
A cloud-based imputation service built on a multi-ancestry reference panel derived from 515,579 jointly phased genomes from the All of Us and AnVIL datasets, establishing a new foundation for genome-wide association studies (GWAS) and fine-mapping, especially in previously underrepresented populations.
Franjo Ivankovic, A. Ko, M. Aster et al.· medRxiv· 0 citations
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