Author

B. Pasaniuc

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Open access Aug 2026

Large-scale admixture mapping in the All of Us Research Program improves the characterization of cross-population phenotypic differences

Admixed individuals have been understudied in medical research largely due to their complex genetic ancestries. However, the consideration of admixture can identify ancestry-enriched genetic associations, delineating genetic underpinnings of cross-population phenotypic variation. Here, we performed admixture mapping in...

R. Mandla, Zhuo-Zheng Shi, Kangcheng Hou et al. · Nature Communications · 0 citations

Open access Aug 2026

A unified framework for local-ancestry-aware genetic association analysis across biobanks

Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...

L. Hu, T. Tan, K. Yuan et al. · medRxiv · 0 citations

Open access Sep 2026

All of Us diversity and scale yield context-dependent improvements in polygenic prediction.

Polygenic risk scores (PRSs) trained on multiancestry data can improve prediction in under-represented groups, but large linked genetic and health datasets capturing broad human diversity remain limited. Using 245,388 whole-genome sequences from the All of Us research program (AoU) together with UK Biobank data, we dev...

K. Tsuo, Zhuo-Zheng Shi, Tian Ge et al. · Nature Genetics · 0 citations