B. Penninx

Parkinsonism and psychopathology severity in real-world outpatients with schizophrenia: A cross-sectional PRISM study.

Extrapyramidal symptoms (EPS) have been described as intrinsic to schizophrenia spectrum disorders (SSD), beyond medication-induced effects. Among EPS, parkinsonism is the most prevalent subtype and has been linked to poorer clinical and functional outcomes. We aimed to examine the relationships between parkinsonism an...

Longitudinal associations between inflammatory biomarkers, polygenic risk scores and cardiometabolic outcomes in major depressive and anxiety disorders: Findings from the Netherlands Study of Depression and Anxiety (NESDA).

Cardiometabolic dysfunctions are prevalent in individuals with major depressive (MDD) and/or anxiety disorders, yet the longitudinal relationships between inflammation, polygenic susceptibility, and cardiometabolic outcomes remain incompletely understood. We analyzed longitudinal data from 2,716 participants retrieved...

Multilingual lexical feature analysis of spoken language for predicting major depression symptom severity.

BACKGROUND Remotely captured spoken language could provide objective, regular indicators of depression symptom severity. However, research to date has largely used non-clinical, cross-sectional written language and complex machine learning (ML) approaches with limited interpretability. METHODS We used linear mixed-ef...

Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort

This study provides hierarchical insights into the cross-sectional and longitudinal implications of health, stress, and lifestyle exposures for the plasma metabolome in the Netherlands Study of Depression and Anxiety.

Distinguishing different psychiatric disorders using DDx-PRS.

Childhood trauma and suicide ideation and attempts: Examining the mediating role of psychosocial, personality, lifestyle and biological factors.

BACKGROUND Childhood trauma (CT) is robustly associated with suicide ideation (SI) and attempts (SA) in individuals with depressive and/or anxiety disorders. However, pathways underlying these associations and whether they differ between suicide ideation only (SI + SA-) and suicide ideation with attempt (SI + SA+) rema...

Atypical energy-related symptoms define biologically distinct subtypes of major depressive disorder

Findings show that the directionality of neurovegetative symptoms indexes genetic heterogeneity within MDD, with metabolic biology as a central axis of differentiation.